Grasping premanifest Huntington's disease – shaping new endpoints for new trials
Identifieur interne : 000698 ( Main/Exploration ); précédent : 000697; suivant : 000699Grasping premanifest Huntington's disease – shaping new endpoints for new trials
Auteurs : Ralf Reilmann [Allemagne] ; Stefan Bohlen [Allemagne] ; Thomas Klopstock [Allemagne] ; Andreas Bender [Allemagne] ; Adolf Weindl [Allemagne] ; Philipp Saemann [Allemagne] ; Dorothee P. Auer [Allemagne] ; Erich B. Ringelstein [Allemagne] ; Herwig W. Lange [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
Abstract
Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23300
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It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name></noRegion><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P." last="Auer">Dorothee P. Auer</name><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B." last="Ringelstein">Erich B. Ringelstein</name><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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